The Bruins (7-6) are in the middle of a four-game losing streak, including three straight double-digit losses. Alford, in his sixth season as UCLA coach, had posted a 124-63 record with four NCAA tournaments and three Sweet 16 appearances.
The 57-year-old Bartow, whose father Gene took over the Bruins program from legendary coach John Wooden in the 1975, joined the current UCLA staff in April 2018.
A graduate assistant on the Bobby Knight-coached 1987 Indiana national championship team, Bartow has an overall record of 328-268 as a head coach. He served six years as head coach at his alma mater of UAB, leading the Blazers to two NIT and one NCAA tournament appearances.
He spent the next 13 years at ETSU with a record of 224-169, which included six postseason appearances. He led the Bucs to two Atlantic Sun Conference tournament championships and one Southern Conference championship with the team sporting a 27-6 overall record in 2003-04.
The Bucs also won the 2007 Atlantic Sun Conference regular-season championship and earned a NIT appearance that season.
After being released by ETSU in October 2015, he joined the staff of South Florida in August 2016. Bartow was named the Bulls interim coach in Jan. 2017, posting a 1-16 record.
Now, he takes over one of the most prestigious programs in college basketball with the Bruins scheduled to host Stanford to open Pac-12 Conference play on Thursday. UCLA holds multiple NCAA Division I records including most national championships (11), most title-game appearances (13) and most consecutive winning seasons (54). UCLA ranks seventh for the most all-time victories and fifth in overall winning percentage behind Kentucky, North Carolina, Kansas and Duke.